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Overview of PST research


Pulsed Signal Therapy, Dr. Cecil Hershler 

      

Pulsed Signal Therapy (a unique form of Pulsed Electromagnetic Field Therapy) has been available for clinical use and research for more than ten years. However, the research on the effect of electrical stimulation on bone dates back to the early 1960s. As a result of that research, Pulsed Electromagnetic Field stimulation of non-union became an established practice and is used in numerous clinics around the world.

Pulsed Signal Therapy (a unique form of Pulsed Electromagnetic Field Therapy) has been available for clinical use and research for more than ten years. However, the research on the effect of electrical stimulation on bone dates back to the early 1960’s. As a result of that research, Pulsed Electromagnetic Field stimulation of non-union became an established practice and is used in numerous clinics around the world. The history of the early research in Pulsed Electromagnetic Fields is well encapsulated in the book “The Body Electric” by Robert O. Becker MD and Gary Selden, William Morrow and Company (1985). This book contains many references to the physiological research behind the electrical stimulation of bone. Andrew Bassett was one of the pioneers that then moved the electrical stimulation method to the electromagnetic form.

Pulsed Signal Therapy: An Overview by Richard Markoll, Dulce Da Silva Ferreira and Theresa K. Toohil published in the Aplar Journal of Rheumatology 2003: Volume 6: pages 89-100 provides an up-to-date explanation and historical summary of Pulsed Signal Therapy. It contains a list of references.

A number of double-blind, randomized, placebo-controlled, trials have been performed and published in peer-reviewed literature. These include:

A Double-Blind Trial of the Clinical Effects of Pulsed Electromagnetic Fields in Osteoarthritis by David H. Trock, Alfred Jay Bollet, Richard H. Dyer Jr., L. Peter Fielding, W. Kenneth Miner and Richard Markoll published in the Journal of Rheumatology 1993 20:3 pages 456-460.

The Effect of Pulsed Electromagnetic Fields and the Treatment of Osteoarthritis of the Knee and Cervical Spine. Report of Randomized, Double-Blind, Placebo-Controlled Trials, by David H. Trock, Alfred Jay Bollet and Richard Markoll published in the Journal of Rheumatology 1994 21: 1903-1911.

Efficacy of Pulsed Electromagnetic Field Therapy in Painful Knee Osteoarthritis: A randomized, double-blind, placebo-controlled study by Serge Perrot, Marc Marty, Andre Khan and Charles-Joel Menkes, Department of Rheumatology, Cochin Hospital, Paris University, Paris published in Arthritis Rheumatology 1998 Volume 41 (3) (suppl) pages 101-104.

Evaluation of Electromagnetic Fields in the Treatment of Pain in Patients with Lumbar Radiculopathy or the Whiplash Syndrome, by Ch. Thuile and M.Walzl, NeuroRehabilitation Volume 17 (2002) pp.63 – 67.

Efficacy of Pulsed Electromagnetic Fields in the Treatment of Early Osteoarthritis of the Knee, by Lim YW, Chong KC, Low CO. Presented at the ECCEO 5, March 16 – 19, 2005, Rome, Italy [Poster: P249].

Exposure to a specific pulsed low-frequency magnetic field: A double-blind placebo-controlled study of effects on pain ratings in rheumatoid arthritis and fibromyalgia patients, by Naomi M. Shupack MSc, Julia C. McKay BSc, Warren R. Nielson PhD, Gary B. Rollman PhD, Frank S Prato PhD, Alex W Thomas PhD. Pain Res Manage Volume 11 No 2 Summer 2006. pp. 85 – 90.

Use of Pulsed Signal Therapy for the Treatment of Pain and Functional Limitation in the context of Arthritic Degenerative Pathology, by De Polo C.; Trenca I.; Frasca M.G.; Rocconi F.; Zorbo S.; Santucci M.; Caraccio V.; Ceccobelli V.; Lazzari M.. University of Rome ‹‹ Tor Vergata›› Dipartamento Di Medicina Critica, Medicina Del Dolore E Delle Scienze Anestesiologiche (Dir. Prof. A.F. Sabato) Servizio Di Fisiopatologia Et Terapai Del Delore Azienda Ospedaliera Universitaria Policlinico Tor Vergata (Resp. Prof.A. Gatti). Poster publication dated March 2007

There are many non-randomized prospective and retrospective studies:

PST (Pulsed Signal Therapy); A Proposal for Chondroprotection with Physical Methods by M. Cossu and N. Portale published in La Riabilitazione, 1998 Volume 31 (2): pages 51-59

Pulsed Signal Therapy: Treatment of Chronic Pain due to Traumatic Soft Tissue Injury by Cecil Hershler and Ana Sjaus published in the International Medical Journal September 1999 Volume 6 (3) pages 167-173.

An entire chapter devoted to Pulsed Signal Therapy was printed in a book, Pain Management: A Practical Guide for Clinicians (6th Edition edited by Richard S. Weiner) CRC Press 2002. This chapter goes through an explanation of the therapy and compares it with other known therapies for a variety of arthritic conditions as well as many other clinical conditions such as tendinitis and ligamentous damage, low back pain etc.

Many research papers have been published on the effect of Pulsed Electromagnetic Fields on animal cartilage. Recently, a number of articles have been published on the effect of Pulsed Signal Therapy on human chondrocytes:

Pulsed Signal Therapy (PST) Stimulates Mitosis of Human Chondrocytes in Culture by H. Gierse, R. Breul, M. Faensen and R. Markoll obtained directly from BMTS Inc., Boca Raton, Florida USA and Munich, Germany.

Pulsed Signal Therapy (PST) Enhances Proteoglycans Concentration in Human Chondrocyte Cultures by the Institute of Rheumatology, University of Siena, Siena, Italy. Obtained directly from BMTS Inc., Boca Raton, Florida USA and Munich, Germany

Biochemical and Morphological Study of Human Articular Chondrocytes Cultivated in the Presence of Pulsed Signal Therapy by A. Fioravanti, F. Nerucci, G. Collodel, R. Markoll and R. Marcolongo published in Ann Rheum Dis 2002; 61 pages 1032-1033.

These were in-vitro studies and provide a physiological basis for the effect of PST on cellular repair.

In 2004, a paper was published describing the effects of Pulsed Electromagnetic Field Therapy on neuropathic pain:

Pulsed Magnetic Field Therapy in Refractory Neuropathic Pain Secondary to Peripheral Neuropathy: Electrodiagnostic Parameters- Pilot Study by Michael I Weintraub and Steven P. Cole published in Neurorehabilitation and Neural Repair 18 (1); 2004 pp.42 - 46.

In 2007, a retrospective study was conducted in Brazil: PST Signals for Motion March 24th 2007 – Helio Zular Zveibil (882 patients evaluated). Reference paper on website: www.certifiedpst.com.

Cecil Hershler, M.D., Ph.D., F.R.C.P. (C)
Updated: March 3, 2010

March 2007: Data analysis of PST effectiveness [PDF]

Technical Explanation

PST is based on the application of a very specific type of pulsed electromagnetic field to bone and adjacent tissues. The PST device generates a pure magnetic field output signal that employs direct current with unidirectional biological frequencies below 30 Hz. The “waveform” is quasi-rectangular with measured field strengths generally below 2 mT or 20 Gauss. The system is controlled through a pulsed unidirectional magnetic DC field with multiple output frequencies implemented via a free-wheeling diode to optimize the inductance characteristics. Various frequency/amplitude combinations are switched over automatically and transmitted under continuous control during the treatment period. Induction of treatment takes place during the first 10 minutes, followed by a combination of pulsed signals that delivers the therapy over the remaining 50 minutes.

In placebo-controlled studies, researchers divide patients either into a control group that receives an active signal during treatment, or a placebo group that doesn't receive an active signal. By comparing the results for both groups, researchers were able to see if the treatment had any effect, or whether patients would have gotten better without the treatment.
In randomized studies, patients are randomly assigned to the groups by a third party. That way, researchers can be sure that the groups are the same in regards to age, sex, physical condition, and other characteristics.
In double-blind studies, neither the patients nor the researchers know until the end of the study who is in the control group and who is in the placebo group.

CLINICAL RESEARCH AND CASE STUDIES

Clinical trials: Pulsed Signal Therapy

Published Pulsed Signal Therapy Research

Pulsed Electromagnetic Fields (PEMF) and intracellular processes

Cell response to pulsed electromagnetic fields (PEMF)

Medical applications of pulsed electromagnetic fields (PEMF)

Case-Study 1   Case-Study 2   Case-Study 3   Case-Study 4   Case-Study 5   Case-Study 6   Case-Study 7   Case-Study 8   Case-Study 9

 
 

 

 
 
 
 
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